Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed ...

Brain cells are constantly swallowing material from the fluid that surrounds them—signaling molecules, nutrients, even pieces of their own surfaces—in a process known as endocytosis that is essential ...

β-Secretase (BACE, Asp-2) is a transmembrane aspartic proteinase responsible for cleaving the amyloid precursor protein (APP) to generate the soluble ectodomain ...

Researchers at Brown University and the Marine Biological Laboratory at Woods Hole, Mass., have found a physical connection between the herpes simplex virus and amyloid precursor protein, a protein ...

A new study strengthens the idea that reelin, an extracellular matrix protein essential for brain development, works, at least in part, by binding amyloid precursor protein (APP). In the June 10 ...

While physicians and scientists have long known that Alzheimer's disease involves the buildup of toxic protein fragments in ...

Alzheimer’s disease can be either sporadic or familial, with common mutations found in amyloid precursor protein (APP) and presenilin genes. The condition can be further classified based by the age of ...

Amyloid fibrils are infamous for the role they play in serious neurological diseases in humans, such as Parkinson's or Alzheimer's. One trigger for Alzheimer's disease is the misfolding and ...

The amyloid protein conformation, a structure that propagates as insoluble fibrils of aggregated β-strand-containing peptides, is a common feature of many neurodegenerative diseases. In Alzheimer, ...

A new study published in the journal JAMA Neurology in April 2020 seems to indicate that higher brain amyloid levels represent early Alzheimer's disease (AD). Amyloid-beta is a significant biomarker ...