Nature

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

The molecular mechanism responsible that determines cell fate after mitotic slippage is unclear. Here we investigate the post-mitotic effects of different mitotic aberrations—misaligned chromosomes ...
The New England Journal of Medicine

Rapid Nanopore Sequencing–Based Screen for Aneuploidy in Reproductive Care

Shown is a universal method for rapid aneuploidy screening of reproductive specimens with the use of short-read transpore rapid karyotyping (STORK). Tissues and cells from chorionic villus sampling ...
ascopubs.org

Clinicopathologic, genomic, and tumor microenvironment correlates of aneuploidy and immunotherapy outcomes in NSCLC.

Use of brain radiotherapy as part of first course of treatment for NSCLC with de novo brain metastasis. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This abstract does not ...
The Conversation

Chromosome errors cause many pregnancies to end before they are even detected

Rajiv McCoy is a co-inventor on a provisional patent related to this work, filed with the United States Patent and Trademark Office (USSN 62/080,251) by Stanford University on Nov. 14, 2014. He has ...