Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

Failure to repair DNA damage can result in DNA lesions and mutations that are a driving factors in cancer development. Recent work has identified a function for DNA damage repair mechanism beyond ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

RNA Polymerase (shown in blue) moves across a template strand of DNA (shown in purple) and transcribes it into RNA (shown in red). But DNA damage blocks the RNA polymerase, causing it to stall and ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Many people lather up with sunscreen or cover up with hats to protect themselves from the sun’s harmful rays. These added layers help to shield the skin from ultraviolet (UV) light, which damages DNA ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Tardigrades, often called water bears or moss piglets, are microscopic creatures that can survive just about anything: boiling heat, freezing cold and crushing pressure. 2 In fact, tardigrades are the ...