MDI Bio Lab scientists discovered how zebrafish solve a basic challenge in regenerative biology—insights in their newest publication in the journal Development could one day guide human repair.

“You’re on a chemotherapeutic and your oncologist may say that your dosage is X, while a nephrologist is telling you that the proximal tubules in your kidneys can’t handle it. You’re harming them.” ...

In videos created by the Hughes Lab to visualize the process, adjacent nephrons form one after the other, as if they were following a beat. “It’s still a hypothesis,” adds Hughes, “but we think that ...

This image, produced by a fluorescence microscope, shows a normal renal proximal tubule, the specific nephron segment in the kidney that is impaired in the rare disease infantile cystinosis. The red, ...

Glomeruli are at the heart of renal function, and yet are only part of an intact nephron. They are of irreplaceable value in maintaining homeostasis. The intact nephron theory: Each nephron is a ...

In the lab, it’s easier to grow simple balls of cells than complex asymmetrical structures with two distinct ends—like the one million filtering units, or nephrons, that make up a human kidney. But ...

The kidney is a masterpiece. The development of the kidney is truly a beautiful process, says Alex Hughes, Assistant Professor of Bioengineering at Penn Engineering and Cell and Developmental Biology ...

A protein, ferritin, protects kidneys against a damaging after-effect of injury, heart failure or hardened arteries by controlling levels of iron, according to a study published today by researchers ...