We defined a case as onset from January 1 to October 31, 2007, of bilateral flaccid paraparesis or paraplegia or retention and incontinence of stool or urine, in a patient receiving intrathecal drugs.

Aug. 2, 2002 -- Prophylactic intrathecal methotrexate significantly reduced recurrence and improved survival for patients in complete remission from aggressive non-Hodgkin's lymphoma (NHL), according ...

“Trying to Be a Good Parent” As Defined By Interviews With Parents Who Made Phase I, Terminal Care, and Resuscitation Decisions for Their Children In this multisite study, 171 children with ...

We describe the clinical spectrum of IT MTX-related SLS, reported in detail in 31 patients treated as part of the UKALL 2003 trial. Concomitant administration of IV cyclophosphamide and cytosine ...

NEW ORLEANS — A study with the worthwhile goal of attempting to further improve outcomes and reduce toxicity of treatment for children and young adults with acute lymphoblastic leukemia (ALL) or ...

You have full access to this article via your institution. The mechanisms involved in this CNS toxicity could be toxic exposure of the cerebellum to ara-C. As has been suggested for methotrexate, the ...

Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse. We conducted a ...

Accord Healthcare, a London-based drugmaker, resumed manufacturing of two methotrexate solutions, according to a Nov. 7 update from the FDA. By March, the American Society of Health-System Pharmacists ...

Methotrexate 1g/vial; pwd for IV, IM, intra-arterial, or intrathecal administration after dilution; preservative-free. Non-metastatic osteosarcoma in patients who have undergone surgical resection or ...

Methotrexate injection, a treatment for certain autoimmune diseases and cancers, can lead to various side effects. These range from common, mild reactions such as headache and nausea to serious, ...