For large-scale industrial production of high-value therapeutic proteins, mammalian cell lines form a vital platform. Unfortunately, this production is often hampered by low predictability and ...
A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...
A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a new study. A ...
Researchers show how repressor proteins ensure accurate gene expression by thwarting histone exchange. Two opposing teams battle it out to regulate gene expression on the DNA playing field. One, the ...
A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...
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