Cellular senescence refers to a state of irreversible arrest of cell proliferation. It was first described by Hayflick and colleagues in the 1960s when they observed cessation of cell proliferation ...

New research from the University of Minnesota Medical School has identified fatty acids that selectively induce death in ...

A new research paper was published in Aging (Aging-US) on March 29, 2025, as the cover of Volume 17, Issue 3, titled "Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: ...

Longevity research always reminds me of the parable of blind men and an elephant. A group of blind men, who’ve never seen an elephant before, each touches a different part of the elephant’s body to ...

Despite all the research happening around understanding Alzheimer’s disease in the past few decades, the reality is that scientists still don’t have great answers for struggling patients. This has led ...

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), ...

Senescent cells are a hallmark of aging. They have also been implicated in a broad spectrum of age-related diseases and conditions including cancer, diabetes, cardiovascular disease, and Alzheimer’s ...

“This work provides new opportunities for the development of the next generation of ChE inhibitors that specifically target AChE and BChE associated with AD pathology.” “This work provides new ...

Mayo Clinic researchers have identified a drug-and-supplement combination therapy that is capable of reducing the harmful effects of senescent cells—also known as "zombie cells"—in diabetic kidney ...

ROCHESTER, Minn. -- Mayo Clinic researchers and colleagues at the University of Minnesota showed that COVID-19 exacerbates the damaging impact of senescent cells in the body. In preclinical studies, ...